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A sustained high-fat diet causes brain shrinkage and waistline enlargement

Metabolic Brain Disease has published the findings of researchers from Australia and China.

According to recent studies, eating fatty foods may not only increase your waistline but also worsen Alzheimer’s disease, cause melancholy, and anxiety.

An international study led by the neuroscientists Professor Xin-Fu Zhou and Associate Professor Larisa Bobrovskaya at the University of South Australia has clearly linked the development of diabetes in mice fed a high-fat diet for 30 weeks to a decline in cognitive function, including anxiety, depression, and worsening Alzheimer’s disease.

Due to poor metabolism brought on by brain alterations, mice with reduced cognitive function were also more prone to put on excessive weight.

Associate Professor Larisa Bobrovskaya, a neurologist and biochemist at the University of South Australia, says the study adds to the growing body of evidence connecting diabetes and obesity with Alzheimer’s disease, which is expected to affect 100 million people worldwide by 2050.

In the experiment, mice were randomised to either a conventional diet or a high-fat diet for 30 weeks beginning at the age of eight weeks. At various intervals, blood sugar levels, body weight, glucose tolerance tests, and cognitive impairment were all evaluated. In comparison to mice fed a standard diet, those on the high-fat diet put on a lot of weight, experienced insulin resistance, and began acting strangely.

When given a high-fat diet, genetically altered Alzheimer’s disease mice displayed a severe decline in cognition and pathological alterations in the brain.

The study proves that cognitive decline, Alzheimer’s disease, and other mental health illnesses are all quite likely to be brought on by a combination of obesity, ageing, and diabetes.

A sustained high-fat diet causes brain shrinkage and waistline enlargement

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